Success during administration

The optimal surfactant experience should start with efficient administration that is easy on your staff and may improve tolerability for your babies.

Explore 3 ways that you and your patients may benefit from CUROSURF administration.

CUROSURF delivers more surfactant with less volume

As the chart below illustrates, with higher surfactant concentration and phospholipid concentration in each dose of CUROSURF, less volume is needed in the baby’s lungs.1-3 Less volume may improve tolerability and has the potential to reduce complications such as airway obstruction.4

Clinical studies have not established that lower volume results in superior efficacy or safety based on clinically relevant end points.

Chart showing more surfactant and less volume
CUROSURF delivers more than twice the phospholipid concentration (mg/mL) of other natural surfactants.1-3

*Based on a 1000-g infant and manufacturer’s dosing schedule.

CUROSURF spreads fast and evenly

CUROSURF is a thin suspension, which has been shown to spread quickly and evenly.5

CUROSURF distribution in lamb lungs over 4 minutes
CUROSURF quickly forms a stable surfactant monolayer inside the alveoli, giving you the option to suction airways after just 1 hour.1,6

†Unpublished photos presented during the CUROSURF Family Meeting, 2000. Preclinical data may not be representative of clinical results.

CUROSURF may improve tolerability and potentially minimize complications during administration

In an observational study, CUROSURF demonstrated relatively quick administration and rapid recovery within 1 minute.7 In addition, CUROSURF demonstrated a low reflux rate, which may improve tolerability and ease of administration.7 It has been suggested that the thin suspension helps to minimize airway and endotracheal tube obstruction and associated complications such as transient hypercapnia.4,7

Administration and reflux rate chart
CUROSURF is a thin suspension that demonstrates a low reflux rate and fast recovery time after administration.1,7

 

Next: CUROSURF efficacy

Explore how the efficacy of CUROSURF can help you experience fast RDS success.

Interested in evaluating CUROSURF? Find out how you can smoothly integrate CUROSURF into your NICU by participating in the CUROSURF Experience Program.
Learn More

Download helpful CUROSURF dosing materials

CUROSURF Wall Dosing Chart

CUROSURF User's Guide

Indication

CUROSURF® (poractant alfa) Intratracheal Suspension is indicated for the treatment (rescue) of respiratory distress syndrome (RDS) in premature infants. CUROSURF reduces mortality and pneumothoraces associated with RDS.

Important Safety Information

CUROSURF is intended for intratracheal use only. THE ADMINISTRATION OF EXOGENOUS SURFACTANTS, INCLUDING CUROSURF, CAN RAPIDLY AFFECT OXYGENATION AND LUNG COMPLIANCE. Therefore, infants receiving CUROSURF should receive frequent clinical and laboratory assessments so that oxygen and ventilatory support can be modified in response to respiratory changes.

CUROSURF should only be administered by those trained and experienced in the care, resuscitation, and stabilization of preterm infants.

TRANSIENT ADVERSE EFFECTS SEEN WITH THE ADMINISTRATION OF CUROSURF INCLUDE BRADYCARDIA, HYPOTENSION, ENDOTRACHEAL TUBE BLOCKAGE, AND OXYGEN DESATURATION. These events require stopping CUROSURF administration and taking appropriate measures to alleviate the condition. After the patient is stable, dosing may proceed with appropriate monitoring.

Click here for full prescribing information

This site is intended for United States residents only.

References: 1. CUROSURF® (poractant alfa) Intratracheal Suspension prescribing information, Cornerstone Therapeutics Inc, September 2009. 2. Survanta® (beractant) Intratracheal Suspension prescribing information, Abbott Laboratories, Inc, March 2009. 3. Infasurf® (calfactant) Intratracheal Suspension prescribing information, ONY, Inc, June 2009. 4. Wiseman LR, Bryson HM. Drugs. 1994;48:386-403. 5. Ingimarsson J, Björklund L, Jonson B, et al. Biol Neonate. 2000;77(suppl 1):24. Abstract 9. 6. Schürch S, Schürch D, Curstedt T, Robertson B. J Appl Physiol. 1994;77:974-986. 7. Gerdes JS, Seiberlich W, Sivieri EM, et al. J Pediatr Pharmacol Ther. 2006;11:92-100.